产品名称
EF-1 α1/2 (Acetyl Lys146) Rabbit Polyclonal Antibody
别名
Elongation factor 1-alpha 1 (EF-1-alpha-1;Elongation factor Tu;EF-Tu;Eukaryotic elongation factor 1 A-1;eEF1A-1;Leukocyte receptor cluster member 7)
基因名称
EEF1A1 EEF1A EF1A LENG7
蛋白名称
EF-1 α1/2 (Acetyl Lys146)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1915
Human Swissprot No.
P68104/Q05639/Q5VTE0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P68104/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13627
Mouse Swissprot No.
P10126
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P10126
Rat Gene Link
https://www.uniprot.org/uniprot/171361
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62630
免疫原
Synthesized peptide derived from human EF-1 α1/2 (Acetyl Lys146)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat EF-1 α1/2 (Acetyl Lys146)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008],
组织表达
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleolus . Cell membrane . Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934). .
功能
caution:Could be the product of a pseudogene.,function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.,similarity:Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.,subunit:Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with XPO5. May interact with ERGIC2.,tissue specificity:Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
