产品名称
Histone H2A.Z (Acetyl Lys12) Rabbit Polyclonal Antibody
蛋白名称
Histone H2A.Z (Acetyl Lys12)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3015
Human Swissprot No.
P0C0S5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P0C0S5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/51788
Mouse Swissprot No.
P0C0S6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P0C0S6
Rat Gene Link
https://www.uniprot.org/uniprot/58940
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0C0S7
免疫原
Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys12)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Histone H2A.Z (Acetyl Lys12)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.,mass spectrometry:Monoisotopic, not modified PubMed:16457589,PTM:Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.,PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.,PTM:Not phosphorylated.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.,
细胞定位
Nucleus. Chromosome.
功能
DNA packaging,?chromatin organization,?chromatin assembly or disassembly,?nucleosome assembly,?chromatin assembly,?cellular macromolecular complex subunit organization,?cellular macromolecular complex assembly,nucleosome organization,?macromolecular complex subunit organization,?chromosome organization,?macromolecular complex assembly,?protein-DNA complex assembly,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
