产品名称
MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody
别名
Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)
蛋白名称
MMP8 (Cleaved-Leu101)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4317
Human Swissprot No.
P22894
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22894/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17394
Mouse Swissprot No.
O70138
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70138
Rat Gene Link
https://www.uniprot.org/uniprot/63849
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88766
免疫原
Synthesized peptide derived from human MMP8 (Cleaved-Leu101)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat MMP8 (Cleaved-Leu101, protein was cleaved amino acid sequence between 100-101 )
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,
细胞定位
Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.
功能
skeletal system development,?ossification,?proteolysis,?collagen catabolic process,?collagen metabolic process,multicellular organismal metabolic process,?multicellular organismal catabolic process,?multicellular organismal macromolecule metabolic process,?bone development,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
