产品名称
Kallikrein-1 (Cleaved-Ile25) Rabbit Polyclonal Antibody
别名
Kallikrein-1 (EC 3.4.21.35;Kidney/pancreas/salivary gland kallikrein;Tissue kallikrein)
蛋白名称
Kallikrein-1 (Cleaved-Ile25)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3816
Human Swissprot No.
P06870/P20151/P07288
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P06870/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16612
Mouse Swissprot No.
P15947
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P15947
Rat Gene Link
https://www.uniprot.org/uniprot/24594
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P00758
免疫原
Synthesized peptide derived from human Kallikrein-1 (Cleaved-Ile25)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Kallikrein-1 (Cleaved-Ile25, protein was cleaved amino acid sequence between 24-25 )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008],
组织表达
Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
功能
catalytic activity:Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.,function:Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.,online information:Kallikrein entry,PTM:The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
