产品名称
ITGAE (light chain, Cleaved-Arg177) Rabbit Polyclonal Antibody
别名
Integrin alpha-E (HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
蛋白名称
ITGAE (light chain, Cleaved-Arg177)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3682
Human Swissprot No.
P38570
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P38570/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16407
Mouse Swissprot No.
Q60677
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60677
免疫原
Synthesized peptide derived from human ITGAE (light chain, Cleaved-Arg177)
特异性
This antibody detects endogenous levels of Human ITGAE (light chain, Cleaved-Arg177, protein was cleaved amino acid sequence between 177-178 )
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],
组织表达
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.,induction:Integrin alpha-E/beta-7 is induced by TGFB1.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 5 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.,tissue specificity:Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
