产品名称
ITGA5 (heavy chain, Cleaved-Arg894) Rabbit Polyclonal Antibody
别名
Integrin alpha-5 (CD49 antigen-like family member E;Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
蛋白名称
ITGA5 (heavy chain, Cleaved-Arg894)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3678
Human Swissprot No.
P08648
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08648/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16402
Mouse Swissprot No.
P11688
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P11688
免疫原
Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)
特异性
This antibody detects endogenous levels of Human,Mouse ITGA5 (heavy chain, Cleaved-Arg894, protein was cleaved amino acid sequence between 894-895 )
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
细胞定位
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .
功能
cell motion,?cell-substrate junction assembly,?cell adhesion,?heterophilic cell adhesion,?leukocyte adhesion,?cell surface receptor linked signal transduction,?integrin-mediated signaling pathway,?behavior,?learning or memory,?memory,response to wounding,?cell-cell adhesion,?cell migration,?biological adhesion,?cell adhesion mediated by integrin,?cell-cell adhesion mediated by integrin,?cell junction assembly,?cell junction organization,?wound healing, spreading of epidermal cells,?wound healing,?cell motility,?neurological system process,?cognition,?localization of cell,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
