产品名称
FA10 (light chain, Cleaved-Arg179) Rabbit Polyclonal Antibody
别名
Coagulation factor X (EC 3.4.21.6;Stuart factor;Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
蛋白名称
FA10 (light chain, Cleaved-Arg179)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2159
Human Swissprot No.
P00742
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P00742/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14058
Mouse Swissprot No.
O88947
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88947
Rat Gene Link
https://www.uniprot.org/uniprot/29243
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63207
免疫原
Synthesized peptide derived from human FA10 (light chain, Cleaved-Arg179)
特异性
This antibody detects endogenous levels of Human FA10 (light chain, Cleaved-Arg179, protein was cleaved amino acid sequence between )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.,function:Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.,online information:Factor X entry,PTM:N- and O-glycosylated.,PTM:The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds.,tissue specificity:Plasma; synthesized in the liver.,
组织表达
Plasma; synthesized in the liver.
功能
proteolysis,?blood coagulation,?blood coagulation, extrinsic pathway,?hemostasis,?response to wounding,?positive regulation of signal transduction,?regulation of protein kinase cascade,?positive regulation of cell communication,positive regulation of protein kinase cascade,?regulation of cell migration,?positive regulation of cell migration,regulation of locomotion,?positive regulation of locomotion,?wound healing,?coagulation,?regulation of body fluid levels,regulation of cell motion,?positive regulation of cell motion,?regulation of protein kinase B signaling cascade,?positive regulation of protein kinase B signaling cascade,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
