产品名称
PDE1A Rabbit Polyclonal Antibody
蛋白名称
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P54750
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54750/entry
Mouse Swissprot No.
Q61481
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61481
免疫原
Synthesized peptide derived from part region of human protein
特异性
PDE1A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009],
组织表达
Several tissues, including brain, kidney, testes and heart.
细胞定位
nucleus,cytosol,neuronal cell body,
信号通路
Purine metabolism;Calcium;Taste transduction;
功能
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a higher affinity for cGMP than for cAMP.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,tissue specificity:Several tissues, including brain, kidney, testes and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
