产品名称
ENTK (light chain, Cleaved-Ile785) Rabbit Polyclonal Antibody
别名
Enteropeptidase (EC 3.4.21.9;Enterokinase;Serine protease 7;Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]
蛋白名称
ENTK (light chain, Cleaved-Ile785)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5651
Human Swissprot No.
P98073
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P98073/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19146
Mouse Swissprot No.
P97435
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97435
免疫原
Synthesized peptide derived from human ENTK (light chain, Cleaved-Ile785)
特异性
This antibody detects endogenous levels of Human ENTK (light chain, Cleaved-Ile785, protein was cleaved amino acid sequence between 785-786 )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.,disease:Defects in PRSS7 are a cause of enterokinase deficiency [MIM:226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.,function:Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.,PTM:The chains are derived from a single precursor that is cleaved by a trypsin-like protease.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 MAM domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SEA domain.,similarity:Contains 1 SRCR domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 LDL-receptor class A domains.,subunit:Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.,tissue specificity:Intestinal brush border.,
组织表达
Intestinal brush border.
细胞定位
Membrane ; Single-pass type II membrane protein .
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
