产品名称
CAMLG Rabbit Polyclonal Antibody
蛋白名称
Calcium signal-modulating cyclophilin ligand (CAML)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49069
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49069/entry
Mouse Swissprot No.
P49070
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P49070
免疫原
Synthesized peptide derived from part region of human protein
特异性
CAMLG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Highest levels in brain, testis and ovary.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.,subunit:The N-terminal domain binds to TNFRSF13B/TACI.,tissue specificity:Ubiquitous. Highest levels in brain, testis and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
