产品名称
DFF45 (Cleaved-Thr225) Rabbit Polyclonal Antibody
别名
DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit;DFF-45;Inhibitor of CAD;ICAD)
蛋白名称
DFF45 (Cleaved-Thr225)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1676
Human Swissprot No.
O00273
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00273/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13347
Mouse Swissprot No.
O54786
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54786
免疫原
Synthesized peptide derived from human DFF45 (Cleaved-Thr225)
特异性
This antibody detects endogenous levels of Human DFF45 (Cleaved-Thr225, protein was cleaved amino acid sequence between 224-225 )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Inhibitor of the caspase-activated DNase (DFF40).,PTM:Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 CIDE-N domain.,subunit:Heterodimer of DFFA and DFFB.,
功能
DNA catabolic process, endonucleolytic,?DNA metabolic process,?DNA catabolic process,?DNA fragmentation involved in apoptosis,?apoptosis,?induction of apoptosis,?cell structure disassembly during apoptosis,?nucleus organization,intracellular signaling cascade,?cell death,?macromolecule catabolic process,?regulation of cell death,?positive regulation of cell death,?programmed cell death,?induction of programmed cell death,?death,?cellular component disassembly,apoptotic nuclear changes,?regulation of apoptosis,?positive regulation of apoptosis,?negative regulation of apoptosis,regulation of programmed cell death,?positive regulation of programmed cell death,?negative regulation of programmed cell death,?cellular macromolecule catabolic process,?negative regulation of cell death,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
