BD-PC0144

Collagen V α2 (Cleaved-Leu1229) Rabbit Polyclonal Antibody

Collagen alpha-2(V) chain

常规抗体

COL5A2

Collagen V α2 (Cleaved-Leu1229)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1290

https://www.uniprot.org/uniprot/1290

P05997

https://www.uniprot.org/uniprotkb/P05997/entry

12832

https://www.uniprot.org/uniprot/12832

Q3U962

https://www.uniprot.org/uniprotkb/Q3U962

Synthesized peptide derived from human Collagen V α2 (Cleaved-Leu1229)

This antibody detects endogenous levels of Human Collagen V α2 (Cleaved-Leu1229, protein was cleaved amino acid sequence between 1229-1230 )

WB 1:1000-2000 ELISA 1:5000-20000

145kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008],

Secreted, extracellular space, extracellular matrix .

disease:Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.,disease:Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome.,disease:Genetic variation in COL5A2 is associated with spontaneous cervical artery dissections (sCAD). sCAD are an important cause of stroke among young and middle-aged patients. Ultrastructural abnormalities are observed in skin biopsies of most patients with sCAD. Major findings included enlarged and irregular collagen fibrils and pronounced elastic fibers fragmentation.,function:Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 VWFC domain.,subunit:Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.