产品名称
Collagen IV α2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody
别名
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
蛋白名称
Collagen IV α2 (Cleaved-Ser1485)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1284
Human Swissprot No.
P08572
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08572/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12827
Mouse Swissprot No.
P08122
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P08122
免疫原
Synthesized peptide derived from human Collagen IV α2 (Cleaved-Ser1485)
特异性
This antibody detects endogenous levels of Human,Mouse Collagen IV α2 (Cleaved-Ser1485, protein was cleaved amino acid sequence between 1485-1486 )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.,similarity:Belongs to the type IV collagen family.,similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.,subunit:There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,
细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane.
功能
negative regulation of angiogenesis,?extracellular matrix organization,?extracellular structure organization,?regulation of angiogenesis,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
