产品名称
CATL1 (heavy chain, Cleaved-Ala114) Rabbit Polyclonal Antibody
别名
Cathepsin L1 (EC 3.4.22.15;Major excreted protein;MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]
蛋白名称
CATL1 (heavy chain, Cleaved-Ala114)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1514
Human Swissprot No.
P07711
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07711/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13039
Mouse Swissprot No.
P06797
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P06797
Rat Gene Link
https://www.uniprot.org/uniprot/25697
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P07154
免疫原
Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)
特异性
This antibody detects endogenous levels of Human CATL1 (heavy chain, Cleaved-Ala114, protein was cleaved amino acid sequence between 113-114 )
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,
细胞定位
Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
