BD-PB3750

IFT57 Rabbit Polyclonal Antibody (Center)

Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI

常规抗体

WB

Human, Mouse

Q9NWB7

This IFT57 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 159-193 amino acids from the Central region of human IFT57.

WB~~1:2000

49kDa

Rabbit Ig

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)

Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia

现货