产品名称
PDE1B Rabbit Polyclonal Antibody
蛋白名称
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01064
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01064/entry
Mouse Swissprot No.
Q01065
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01065
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q01066
免疫原
Synthesized peptide derived from part region of human protein
特异性
PDE1B Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
组织表达
Brain,Human uterus,Testis,
细胞定位
Cytoplasm, cytosol .
信号通路
Purine metabolism;Calcium;
功能
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a preference for cGMP as a substrate.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
