产品名称
GBA2 Rabbit Polyclonal Antibody (Center)
别名
Non-lysosomal glucosylceramidase, NLGase, 3.2.1.45, Beta-glucocerebrosidase 2, Beta-glucosidase 2, Glucosylceramidase 2, GBA2, KIAA1605
Human Swissprot No.
Q9HCG7
特异性
This GBA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 593-623 amino acids from the Central region of human GBA2.
背景介绍
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
组织表达
Widely expressed (PubMed:11489889). Mainly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower levels in liver, spleen, small intestine and lung (PubMed:11489889). Detectable in colon, thymus and peripheral blood leukocytes (PubMed:11489889).
细胞定位
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q69ZF3}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q69ZF3}. Note=Localization to the plasma membrane and alternative topologies have also been reported
