BD-PB3672

STT3A Rabbit Polyclonal Antibody (Center)

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, Oligosaccharyl transferase subunit STT3A, STT3-A, 2.4.99.18, B5, Integral membrane protein 1, Transmembrane protein TMC, STT3A, ITM1, TMC

常规抗体

WB

Human, Mouse

P46977

This STT3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 476-507 amino acids from the Central region of human STT3A.

WB~~1:2000

81kDa

Rabbit Ig

Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.

Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney Expressed in skin fibroblasts (at protein level)

Endoplasmic reticulum. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P46978}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46978}

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