BD-PB3622-MLL3(5O15)Mouse Monoclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

MLL3(5O15)Mouse Monoclonal Antibody

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产品基本信息

产品货号

BD-PB3622

产品名称

MLL3(5O15)Mouse Monoclonal Antibody

别名

Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Swissprot No.

Q8NEZ4

特异性

This MLL3 antibody is generated from a mouse immunized with a recombinant protein of human MLL3.

稀释度

WB~~1:2000

预测分子量

541kDa

同种型

IgG1,k

背景介绍

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

组织表达

Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver

细胞定位

Nucleus.

期货

现货

Anti-MLL3 Antibody at 1:2000 dilution + Recombinant protein Lysates/proteins at 20 ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 541 kDa Blocking/Dilution buffer: 5% NFDM/TBST.