产品名称
B4GN2 Rabbit Polyclonal Antibody
蛋白名称
Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NHY0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NHY0/entry
Mouse Swissprot No.
Q09199
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q09199
免疫原
Synthesized peptide derived from part region of human protein
特异性
B4GN2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
beta-1,4-N-acetyl-galactosaminyltransferase 2(B4GALNT2) Homo sapiens B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008],
组织表达
Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
function:Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 2,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,tissue specificity:Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
