产品名称
MGAT4A Rabbit Polyclonal Antibody (N-Term)
别名
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa, GlcNAc-T IVa, GnT-IVa, N-acetylglucosaminyltransferase IVa, UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa, Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form, MGAT4A
Human Swissprot No.
Q9UM21
特异性
This MGAT4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-102 amino acids from human MGAT4A.
背景介绍
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
组织表达
Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer.
细胞定位
[Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A]: Golgi apparatus membrane; Single-pass type II membrane protein
