产品名称
MTUS1 Rabbit Polyclonal Antibody (N-Term)
别名
Microtubule-associated tumor suppressor 1, AT2 receptor-binding protein, Angiotensin-II type 2 receptor-interacting protein, Mitochondrial tumor suppressor 1, MTUS1, ATBP, ATIP, GK1, KIAA1288, MTSG1
Human Swissprot No.
Q9ULD2
特异性
This MTUS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 183-226 amino acids from human MTUS1.
背景介绍
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
组织表达
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart Within brain it is highly expressed in corpus callosum and pons Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
细胞定位
Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
