产品名称
IRK15 Rabbit Polyclonal Antibody
蛋白名称
ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99712
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99712/entry
Mouse Swissprot No.
O88932
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88932
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q91ZF1
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
IRK15 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013],
细胞定位
Membrane; Multi-pass membrane protein.
功能
function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Interacts with INADL.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.