产品名称
B4GT6 Rabbit Polyclonal Antibody
蛋白名称
Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6) [Includes: Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBX8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBX8/entry
Mouse Swissprot No.
Q9WVK5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVK5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O88419
免疫原
Synthesized peptide derived from part region of human protein
特异性
B4GT6 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Ju
组织表达
High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.
细胞定位
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Trans cisternae of Golgi stack. .
信号通路
Sphingolipid metabolism;
功能
catalytic activity:UDP-galactose + glucosylceramide = UDP + lactosylceramide.,cofactor:Manganese or magnesium or calcium.,enzyme regulation:Inhibited by EDTA.,function:Required for the biosynthesis of glycosphingolipids.,online information:Beta-1,4-galactosyltransferase 6,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
