产品名称
IRK14 Rabbit Polyclonal Antibody
蛋白名称
ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UNX9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UNX9/entry
Mouse Swissprot No.
Q8JZN3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8JZN3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O70596
免疫原
Synthesized peptide derived from human protein . at AA range: 350-430
特异性
IRK14 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013],
组织表达
Expressed preferentially in retina.
细胞定位
Membrane; Multi-pass membrane protein.
功能
function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,tissue specificity:Expressed preferentially in retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
