产品名称
PIF1 Rabbit Polyclonal Antibody
蛋白名称
ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (PIF1/RRM3 DNA helicase-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H611
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H611/entry
Mouse Swissprot No.
Q80SX8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80SX8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q1HG60
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
PIF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013],
组织表达
Weak ubiquitous expression.
细胞定位
Nucleus .; [Isoform 4]: Mitochondrion .
功能
function:DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase.,similarity:Belongs to the helicase family.,subunit:Interacts with telomerase.,tissue specificity:Weak ubiquitous expression.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
