BD-PB3405

NGEF Rabbit Polyclonal Antibody (N-term)

Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF

常规抗体

WB

Human, Rat, Mouse

Q8N5V2

This NGEF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-220 amino acids from the N-terminal region of human NGEF.

WB~~1:1000-1:2000

82kDa

Rabbit Ig

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.

Cytoplasm. Membrane. Cell projection, growth cone. Note=Associated with membranes. Localizes to axonal growth cones (By similarity)

现货