产品名称
ABCA9 Rabbit Polyclonal Antibody
蛋白名称
ATP-binding cassette sub-family A member 9
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IUA7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IUA7/entry
Mouse Swissprot No.
Q8K449
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K449
免疫原
Synthesized peptide derived from human protein . at AA range: 800-880
特异性
ABCA9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with higher expression in heart.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
developmental stage:Expressed in fetal tissues with higher expression in fetal heart and kidney.,function:May play a role in monocyte differentiation and lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
