BD-PB3289-FBXW7 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

FBXW7 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB3289

产品名称

FBXW7 Rabbit Polyclonal Antibody (N-term)

别名

F-box/WD repeat-containing protein 7, Archipelago homolog, hAgo, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, hCdc4, FBXW7 (HGNC:16712)

类别

常规抗体

推荐应用

反应种属

Human

Human Swissprot No.

Q969H0

特异性

This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-167 amino acids from the N-terminal region of human FBXW7.

稀释度

WB~~1:2000

预测分子量

80kDa

同种型

Rabbit Ig

背景介绍

Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

组织表达

[Isoform 1]: Widely expressed.

细胞定位

[Isoform 1]: Nucleus, nucleoplasm. Chromosome Note=Localizes to site of double-strand breaks following phosphorylation by ATM. [Isoform 3]: Nucleus, nucleolus

期货

现货

Anti-FBXW7 Antibody (N-term)at 1:2000 dilution + Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 80 kDa Blocking/Dilution buffer: 5% NFDM/TBST.