BD-PB3262

Mouse Alk Rabbit Polyclonal Antibody (P1517)

ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, Alk

常规抗体

WB

Mouse

P97793

This Mouse Alk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1517-1550 amino acids Mouse Alk.

WB~~1:2000

175kDa

Rabbit Ig

Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Mainly expressed in central nervous system (CNS) and other parts of the brain such as the paraventricular nucleus (PVN) of the hypothalamus. Expression is also found in peripheral nervous systems, eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach, midgut, as well as testis and ovary.

Cell membrane {ECO:0000250|UniProtKB:Q9UM73}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9UM73} Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. {ECO:0000250|UniProtKB:Q9UM73}

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