产品名称
DCTN3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11258
Human Swissprot No.
O75935
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75935/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/53598
Mouse Swissprot No.
Q9Z0Y1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z0Y1
免疫原
Synthesized peptide derived from human DCTN3 AA range: 117-167
特异性
This antibody detects endogenous levels of DCTN3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cleavage furrow . Midbody . Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
功能
function:Together with dynein may be involved in spindle assembly and cytokinesis.,similarity:Belongs to the dynactin subunit 3 family.,subcellular location:Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.,subunit:Subunit of dynactin, a multiprotein complex associated with dynein.,tissue specificity:Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
