产品名称
RFOX1 Rabbit Polyclonal Antibody
基因名称
RBFOX1 A2BP A2BP1 FOX1 HRNBP1
蛋白名称
RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NWB1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NWB1/entry
Mouse Swissprot No.
Q9JJ43
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJ43
免疫原
Synthesized peptide derived from human protein . at AA range: 50-130
特异性
RFOX1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
组织表达
Predominantly expressed in muscle and brain.
细胞定位
Nucleus . Cytoplasm .
功能
function:RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Binds to the C-terminal of ATXN2.,tissue specificity:Predominantly expressed in muscle and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
