产品名称
ATX10 Rabbit Polyclonal Antibody
蛋白名称
Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBB4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBB4/entry
Mouse Swissprot No.
P28658
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P28658
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9ER24
免疫原
Synthesized peptide derived from human protein . at AA range: 10-90
特异性
ATX10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016],
组织表达
Expressed in the central nervous system.
细胞定位
Cytoplasm, perinuclear region .
功能
disease:Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).,similarity:Belongs to the ataxin-10 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
