产品名称
(Mouse) Epha1 Rabbit Polyclonal Antibody (Center)
别名
Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Human Swissprot No.
Q60750
特异性
This mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 453-487 amino acids from the Central region of mouse Epha1.
背景介绍
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
组织表达
Preferentially expressed in epithelial cells including skin, kidney, liver and thymus (PubMed:11519828, PubMed:18802966). Expressed in myogenic progenitor cells (PubMed:27446912).
细胞定位
Cell membrane; Single-pass type I membrane protein
