BD-PB3196

(Mouse) Sox2 Rabbit Polyclonal Antibody (N-term)

Transcription factor SOX-2, Sox2, Sox-2

常规抗体

WB

Human, Mouse

P48432

This Mouse Sox2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 34-68 amino acids from the N-terminal region of mouse Sox2.

WB~~1:1000

34kDa

Rabbit Ig

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Expressed in the cochlea (at protein level) (PubMed:32127020). Expressed in the brain and retina (PubMed:7590241, PubMed:15863505). A very low level of expression is seen in the stomach and lung (PubMed:7590241, PubMed:15863505). Expressed in the kidney (PubMed:15863505).

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:32127020}

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