产品名称
AAA1 Rabbit Polyclonal Antibody
蛋白名称
Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NS82
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NS82/entry
Mouse Swissprot No.
P63115
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63115
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P63116
免疫原
Synthesized peptide derived from human protein . at AA range: 200-280
特异性
AAA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
disease:Defects in SLC7A10 may be involved in cystinuria (CSNU) which arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described.,function:Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.,similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily.,subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
