产品名称
NACC1 Rabbit Polyclonal Antibody (C-term)
别名
Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B, NACC1, BTBD14B, NAC1
Human Swissprot No.
Q96RE7
特异性
This NACC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-390 amino acids from the C-terminal region of human NACC1.
背景介绍
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
组织表达
Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
细胞定位
Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation.
