产品名称
ATE1 Rabbit Polyclonal Antibody
蛋白名称
Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95260
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95260/entry
Mouse Swissprot No.
Q9Z2A5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2A5
免疫原
Synthesized peptide derived from human protein . at AA range: 400-480
特异性
ATE1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
组织表达
Embryonic kidney,Testis,
细胞定位
[Isoform ATE1-1]: Nucleus . Cytoplasm .; [Isoform ATE1-2]: Cytoplasm .
功能
catalytic activity:L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.,caution:It is uncertain whether Met-1 or Met-37 is the initiator.,function:Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the R-transferase family.,subunit:Monomer .,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
