产品名称
AQP9 Rabbit Polyclonal Antibody
蛋白名称
Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43315
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43315/entry
Mouse Swissprot No.
Q9JJJ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJJ3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P56627
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
AQP9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
组织表达
Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
