产品名称
(Mouse) Sox17 Rabbit Polyclonal Antibody (C-term)
别名
Transcription factor SOX-17, Sox17, Sox-17
Human Swissprot No.
Q61473
特异性
This (Mouse) Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 376-409 amino acids from the C-terminal region of mouse Sox17.
背景介绍
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.
组织表达
Detected in lung and testis (PubMed:8636240). Detected in endothelial cells around small and large arteries in newborns and adults, but is barely detectable in veins (at protein level) (PubMed:24153254). Detected in lung and testis (PubMed:8636240)
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:20802155, ECO:0000269|PubMed:24153254, ECO:0000269|PubMed:8636240}
