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ANT3 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PN0451
产品名称
ANT3 Rabbit Polyclonal Antibody
类别
常规抗体
基因名称
SERPINC1 AT3 PRO0309
蛋白名称
Antithrombin-III (ATIII) (Serpin C1)
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene ID
462
Human Swissprot No.
P01008
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01008/entry
Mouse Swissprot No.
P32261
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P32261
免疫原
Synthesized peptide derived from human protein . at AA range: 1-80
特异性
ANT3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
预测分子量
51kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009],
组织表达
Found in plasma.
细胞定位
Secreted, extracellular space.
信号通路
Complement and coagulation cascades;
功能
disease:Defects in SERPINC1 are the cause of antithrombin-III deficiency (AT3D) [MIM:107300]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.,function:Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.,mass spectrometry: PubMed:7734359,mass spectrometry:Variant Thr-414 PubMed:7734359,online information:Antithrombin entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the serpin family.,tissue specificity:Found in plasma.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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