BD-PB3064

Mouse Hes1 Rabbit Polyclonal Antibody (Center)

Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1

常规抗体

WB

Human, Rat, Mouse

P35428

This Mouse Hes1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of Mouse Hes1.

WB~~1:1000

30kDa

Rabbit Ig

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds

Nucleus.

现货