产品名称
ANX11 Rabbit Polyclonal Antibody
蛋白名称
Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P50995
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50995/entry
Mouse Swissprot No.
P97384
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97384
免疫原
Synthesized peptide derived from human protein . at AA range: 280-360
特异性
ANX11 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015],
组织表达
Brain,Kidney,Lymph,Teratocarcinoma,Trachea,
细胞定位
Cytoplasm . Melanosome. Nucleus envelope. Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, spindle. Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. .
功能
disease:Antibodies against ANXA11 are present in sera from patients with various autoimmune diseases, predominantly in sera from patients with rheumatoid arthritis, systemic lupus erythematosus, or Sjoegren syndrome.,domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:Found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
