产品名称
AMOT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q4VCS5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q4VCS5/entry
Mouse Swissprot No.
Q8VHG2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHG2
免疫原
Synthesized peptide derived from human protein . at AA range: 710-790
特异性
AMOT Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
细胞定位
Cell junction, tight junction . Localized on the cell surface. May act as a transmembrane protein.
功能
domain:The angiostatin binding domain (871-1005) allows the binding to angiostatin.,domain:The coiled coil domain interacts directly with the BAR domain of ARHGAP17.,function:Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.,miscellaneous:'Motus' means motility in Latin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the angiomotin family.,subcellular location:Localized on the cell surface. May act as a transmembrane protein.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.,tissue specificity:Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
