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Mouse Itk Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号
BD-PB2982
产品名称
Mouse Itk Rabbit Polyclonal Antibody (N-term)
别名
Tyrosine-protein kinase ITK/TSK, IL-2-inducible T-cell kinase, Kinase EMT, Kinase TLK, T-cell-specific kinase, Itk, Emt, Tlk, Tsk
类别
常规抗体
推荐应用
WB
反应种属
Human, Mouse
Human Swissprot No.
Q03526
特异性
This Mouse Itk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 156-190 amino acids from the N-terminal region of human Mouse Itk.
稀释度
WB~~1:1000
预测分子量
72kDa
同种型
Rabbit Ig
背景介绍
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
组织表达
Is detected in the thymus, lymph node and very faintly in the spleen, but is not detected in the liver, lung, kidney, heart, brain, intestine or testis. Expressed in T-lymphocytes and mast cells. It may also be expressed in natural killer cells
细胞定位
Cytoplasm. Nucleus. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
期货
现货

Western blot analysis of lysates from mouse thymus and mouse spleen tissue lysate (from left to right), using Mouse Itk Antibody (N-term). BD-PB2982 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

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