BD-PB2958-AFAP1-Y451 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

AFAP1-Y451 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PB2958

产品名称

AFAP1-Y451 Rabbit Polyclonal Antibody

别名

Actin filament-associated protein 1, 110 kDa actin filament-associated protein, AFAP-110, AFAP1, AFAP

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

Human Swissprot No.

Q8N556

特异性

This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 444-477 amino acids from human.

稀释度

WB~~1:1000

预测分子量

81kDa

同种型

Rabbit Ig

背景介绍

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

组织表达

Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma

细胞定位

Cytoplasm, cytoskeleton, stress fiber

期货

现货

Western blot analysis of lysates from Hela, MCF-7, MDA-MB-231, MDA-MB-453 cell line (from left to right), using AFAP1-Y451. BD-PB2958 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.