产品名称
Sqstm1(S351) Rabbit Polyclonal Antibody
别名
Sequestosome-1, STONE14, Ubiquitin-binding protein p62, Sqstm1, A170, STAP
Human Swissprot No.
Q64337
特异性
This Phospho-Sqstm1(S351) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 346-379 amino acids from the human region of human Phospho-Sqstm1(S351).
背景介绍
Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
细胞定位
Cytoplasm, cytosol. Late endosome. Nucleus Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome Nucleus, PML body {ECO:0000250|UniProtKB:Q13501}. Cytoplasm, myofibril, sarcomere. Note=In cardiac muscles, localizes to the sarcomeric band (By similarity). May also localize to the hepatocellular carcinoma (By similarity). Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (PubMed:20421418). Co- localizes with TRIM5 in the cytoplasmic bodies (By similarity). When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies (By similarity). {ECO:0000250|UniProtKB:Q13501, ECO:0000269|PubMed:20421418}