产品名称
Rat-Cebpb-S105 Rabbit Polyclonal Antibody
别名
CCAAT/enhancer-binding protein beta, C/EBP beta, C/EBP-related protein 2, Interleukin-6-dependent-binding protein, IL-6DBP, Liver-enriched inhibitory protein, LIP, Liver-enriched transcriptional activator, LAP, Silencer factor B, SF-B, Cebpb, Crp2, Sfb
Human Swissprot No.
P21272
特异性
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-131 amino acids from rat.
背景介绍
Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).
细胞定位
Nucleus {ECO:0000250|UniProtKB:P17676}. Cytoplasm {ECO:0000250|UniProtKB:P17676}. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250|UniProtKB:P17676, ECO:0000250|UniProtKB:P28033}
