产品名称
AAT1 Rabbit Polyclonal Antibody
蛋白名称
AMY-1-associating protein expressed in testis 1 (AAT-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7Z4T9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z4T9/entry
Mouse Swissprot No.
Q8BRC6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BRC6
免疫原
Synthesized peptide derived from human protein . at AA range: 310-390
特异性
AAT1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
alternative products:Additional isoforms (AAT-1L and AAT-1S) may exist,function:Isoform 4 may play a role in spermatogenesis.,PTM:Isoform 4 is phosphorylated by PKA.,subcellular location:Isoform 4 is found in the mitochondria and localized in the neck of the sperm.,subunit:Interacts with AMY1 and AKAP1. Isoform 4 belongs to a complex together with AMY1, AKAP1 and PRKAR2B. Isoform 3 does not interact with AMY1.,tissue specificity:Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis. Isoform 4 is present in the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.,
组织表达
[Isoform 1]: Strongly expressed in the liver.; [Isoform 7]: Widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Also expressed in Leydig cells.
细胞定位
Mitochondrion . Cytoplasm . Cytoplasm, cytoskeleton, cilium axoneme . Localized in the neck of the sperm.; [Isoform 7]: Cytoplasm .
功能
alternative products:Additional isoforms (AAT-1L and AAT-1S) may exist,function:Isoform 4 may play a role in spermatogenesis.,PTM:Isoform 4 is phosphorylated by PKA.,subcellular location:Isoform 4 is found in the mitochondria and localized in the neck of the sperm.,subunit:Interacts with AMY1 and AKAP1. Isoform 4 belongs to a complex together with AMY1, AKAP1 and PRKAR2B. Isoform 3 does not interact with AMY1.,tissue specificity:Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis. Isoform 4 is present in the spermatid and mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
