产品名称
A2AP Rabbit Polyclonal Antibody
蛋白名称
Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P08697
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08697/entry
Mouse Swissprot No.
Q61247
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61247
免疫原
Synthesized peptide derived from human protein . at AA range: 390-470
特异性
A2AP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
组织表达
Expressed by the liver and secreted in plasma.
信号通路
Complement and coagulation cascades;
功能
disease:Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis.,function:The major targets of this inhibitor are plasmin and trypsin, but it also inactivates chymotrypsin.,similarity:Belongs to the serpin family.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
