产品名称
A1ATR Rabbit Polyclonal Antibody
基因名称
SERPINA2 ARGS ATR PIL
蛋白名称
Putative alpha-1-antitrypsin-related protein (Serpin A2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P20848
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20848/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
A1ATR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014],
组织表达
Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.
细胞定位
Endoplasmic reticulum .
功能
caution:Could be the product of a pseudogene.,domain:The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.,function:Could be a serine protease inhibitor.,similarity:Belongs to the serpin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
